The highest recorded temperature is 52.7 ☌ (126.9 ☏), recorded in May 1998 and the lowest recorded temperature is −4 ☌ (24.8 ☏), recorded in January 1929. Larkana has a hot desert climate ( Köppen climate classification BWh) with sweltering summers and mild winters. It is situated in northwest part of Sindh and it has own division. Larkana is situated at Latitude 24 56' 00' and Longitude 67 11' 00'. Moreover, Larkana city has been placed as fifteenth largest of Pakistan during Census 2017. Therefore, it is the fourth most populated city of Sindh province after Karachi, Hyderabad, and Sukkur. According to the 2017 Census of Pakistan, its population is 490,508. Formerly known as ' Chandka', Larkana is located on the south bank of the Ghar canal, about 40 miles (64 km) south of the town Shikarpur, and 36 miles (58 km) northeast of Mehar.

The city is located within Larkana District. The historic Indus River flows in east and south of the city. It is home to the Indus Valley civilization site Mohenjo-daro. It is the 15th largest city of Pakistan by population.

Larkana ( Urdu: لاڑکانہ, romanized: lāṛkāna Sindhi: لاڙڪاڻو, romanized: lāṛkāṇo) is a city located in the Sind province of Pakistan.

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